HIV Orange
AIDS Vaccine Basics is comprised of our popular Primer series, textbook-like chapters of about 800 words each that aim to translate the complex world of AIDS vaccine science into simple but informative language. Here you will find deftly written explanations on how different AIDS vaccine strategies work, what cells comprise the different arms of the human immune system, and how to interpret the results of AIDS vaccine trials. The page contains a searchable key that allows readers to track down Primer topics dating back to 2003.

Understanding Partial Efficacy
What is a partially effective vaccine?
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Understanding if Broadly Neutralizing Antibodies are the Answer
VAX May 2010

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Understanding Vaccine Development
How are vaccines developed?
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Understanding Advances in the Search for Antibodies Against HIV
VAX March 2010
What are some of the recent developments that are helping researchers identify new targets for HIV vaccine design?
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Understanding the Immune System, Part II
How do AIDS vaccines prepare different parts of the immune system to fight HIV?
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Understanding Antibody Functions: Beyond Neutralization
VAX January 2010
What other antibody functions are being explored to explain the RV144 results?
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Understanding Vaccine Licensure
Vax December 2009
What factors do regulatory bodies consider before licensing a vaccine for public use?
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Understanding the Immune System, Part I
How do vaccines interact with the immune system?
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Understanding the Hunt for Immune Correlates of Protection from RV144
Vax November 2009
How can the recently conducted AIDS vaccine trial in Thailand help inform researchers about the types of immune responses that can provide protection against HIV?
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Understanding the Statistical Analysis of Clinical Trial Results
Vax October 2009
What are some of the statistical methods that are used to interpret clinical trial results?
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Understanding Trial Approval
How does an AIDS vaccine trial gain official approval and community support?
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Understanding Challenge Viruses
Vax September 2009
How does the choice of challenge virus affect the outcome of vaccine studies in nonhuman primates?
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Understanding the Role of Social Science Research in Clinical Trials
Vax August 2009
What can researchers learn from studying communities in preparation for AIDS vaccine clinical trials?
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Understanding Routes of Transmission
Why do vaccines need to be tested in different populations?
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Understanding Inclusion/Exclusion Criteria
Vax July 2009
What are come of the eligibility requirements for volunteers to participate in AIDS vaccine clinical trials?
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Understanding Viral Diversity
Why are there so many different versions of HIV?
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Understanding How Data is Collected in Clinical Trials
Vax June 2009
What are the methods used to ensure that data from AIDS vaccine trials are of high quality?
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Understanding How Partially Effective Vaccine Candidates are Evaluated
Vax May 2009
What are some of the complications in designing trials to study partially effective AIDS vaccine candidates?
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Understanding Vaccine Trials
How are AIDS vaccines tested?
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Understanding the Transmitted Virus
Vax April 2009
What are researchers learning about the enemy that a preventive AIDS vaccine would need to block—the virus that is transmitted and establishes infection?
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