HIV Orange
AIDS Vaccine Basics is comprised of our popular Primer series, textbook-like chapters of about 800 words each that aim to translate the complex world of AIDS vaccine science into simple but informative language. Here you will find deftly written explanations on how different AIDS vaccine strategies work, what cells comprise the different arms of the human immune system, and how to interpret the results of AIDS vaccine trials. The page contains a searchable key that allows readers to track down Primer topics dating back to 2003.

Understanding How Partially Effective Vaccine Candidates are Evaluated
Vax May 2009
What are some of the complications in designing trials to study partially effective AIDS vaccine candidates?
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Understanding the Transmitted Virus
Vax April 2009
What are researchers learning about the enemy that a preventive AIDS vaccine would need to block—the virus that is transmitted and establishes infection?
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Understanding How Inserts for Vaccine Candidates are Designed
Vax March 2009
What strategies are being explored to design better inserts for inclusion in AIDS vaccine candidates?
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Understanding How Immune Responses to AIDS Vaccine Candidates are Measured
Vax February 2009
What are the limitations of current methods used to analyze immune responses to AIDS vaccine candidates and what new strategies are being explored?
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Understanding the Conundrum of Immune Activation in HIV/AIDS
Vax January 2009
Why is it that chronic activation of the immune system during HIV infection actually leads to disease progression?
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Understanding Innate Immunity and HIV
VAX December 2008
What role do innate immune responses play in defending against HIV infection?
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Understanding Approaches to Inducing Neutralizing Antibodies
VAX November 2008
What are some of the novel approaches researchers are exploring to induce broadly neutralizing antibodies against HIV?
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Understanding Animal Models of HIV Infection
VAX October 2008
What are the limitations of the animal models used by researchers to evaluate AIDS vaccine candidates?
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Understanding Control of Virus Replication
VAX September 2008
What can researchers learn from studying how some species of nonhuman primates can control infection with SIV?
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Understanding the Genetic Variation of HIV
VAX August 2008
What are the implications of the genetic diversity of HIV for AIDS vaccine development?
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Understanding Live-Attenuated Vaccines
VAX June 2008
What can AIDS vaccine researchers learn from live-attenuated SIV vaccines?
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Understanding the Recruitment of Volunteers at Risk of HIV Infection
VAX May 2008
Why are volunteers who are at high risk of HIV infection necessary participants in late-stage AIDS vaccine trials?
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Understanding Cellular Immune Responses
VAX April 2008
What is known about cellular immune responses against HIV?
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Understanding the Recruitment and Retention of Women in Clinical Trials
VAX March 2008
What are some of the considerations regarding recruitment and retention of women in AIDS vaccine clinical trials?
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Understanding Biostatistics and the STEP Trial
How are statisticians analyzing the data from the STEP trial?
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Understanding HIV Transmission
What events lead to the sexual transmission of HIV and how can mucosal immune responses protect against infection?
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Understanding Replicating Viral Vectors
What are the advantages of using replicating viral vectors in AIDS vaccine research?
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Understanding Randomized, Controlled Clinical Trials
What are randomized, controlled, double-blind clinical trials?
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Understanding Immunogenicity
How do researchers measure the immune responses induced by AIDS vaccine candidates?
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Understanding HIV Incidence
Why are HIV incidence rates important for AIDS vaccine trials?
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